Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1b Release

Hemin Induces the Activation of NLRP3 Inflammasome in N9 Microglial Cells

Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. Objective: To investigate w...

Title of Document: Activation of NLRP3 inflammasomes during complement-mediated phagocytosis by macrophages

Title of Document: Activation of NLRP3 inflammasomes during complement-mediated phagocytosis by macrophages Rahul Suresh, Doctor of Philosophy, 2015 Directed by: Dr. David M. Mosser, Professor Department of Cell Biology & Molecular Genetics The Complement System is an important component of innate immunity, whose activation has been associated with acute inflammation. Activation of complement l...

CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a pre...

ADP-Ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS Toxin Regulates Inflammasome Activity

UNLABELLED The inflammasome is a major regulator of inflammation through its activation of procaspase-1, which cleaves prointerleukin-1β (pro-IL-1β) into its mature form. IL-1β is a critical proinflammatory cytokine that dictates the severity of inflammation associated with a wide spectrum of inflammatory diseases. NLRP3 is a key component of the inflammasome complex, and multiple signals and s...